DUSP6

Across TCGA pan-cancer cohorts, DUSP6 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DUSP6 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher DUSP6 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DUSP6 expression acts as an unfavorable survival marker.

PDAC, LSCC, and LUAD are the cancer types where DUSP6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	III,IV	0.139	0.766	.038	12	view →
LSCC	OS	Median	II,III,IV	0.658	0.857	.035	2	view →
LUAD	OS	Quartile	II,III,IV	0.373	0.705	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DUSP6–PDAC (OS)

Open the PDAC breakdown →