DUSP5

Across TCGA patient cohorts, DUSP5 mutation is significantly associated with the RNA expression of many other genes, with 1,123 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DUSP5-associated genes across cancer lineages are MIR6859-3, RNU1-17P, and RNA5SP248. Each is linked with DUSP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUSP5-to-partner and partner-to-DUSP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6859-3 grouped by DUSP5-low versus DUSP5-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUSP5→partner) and Y-score (partner→DUSP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR6859-3 →	+0.516	+7.164	<.001	<.001	3	2
UCEC	RNU1-17P →	+0.228	+2.450	<.001	.003	3	2
UCEC	RNA5SP248 →	+0.464	+2.794	<.001	<.001	3	2
UCEC	RNU6-1122P →	+0.241	+2.452	<.001	.008	3	2
UCEC	TRAJ1 →	+0.474	+2.163	<.001	.003	3	2
LGG	RNU6-99P →	+0.248	+7.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,123 associations by consensus.

MIR6859-3 by DUSP5 expression — CESC

Explore this box plot interactively →