DUSP5

Across TCGA cell cohorts, DUSP5 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,212 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DUSP5-associated GO terms across cancer lineages are Peptidyl-threonine dephosphorylation, Negative regulation of MAPK cascade, and Peptidyl-tyrosine dephosphorylation. Each is linked with DUSP5 in more than 13 cancer types. Because this analysis shows association rather than direction, both DUSP5-to-partner and partner-to-DUSP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptidyl-threonine dephosphorylation grouped by DUSP5-low versus DUSP5-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DUSP5→partner) and Y-score (partner→DUSP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Peptidyl-threonine dephosphorylation →	+0.185	+2.411	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Negative regulation of MAPK cascade →	+0.092	+3.020	<.001	.001	3	13
URINARY_TRACT	Peptidyl-tyrosine dephosphorylation →	+0.121	+1.953	<.001	<.001	3	13
CNS	Dephosphorylation →	+0.032	+1.027	<.001	<.001	3	10
LUNG_SCLC	Endoderm formation →	+0.171	+2.023	<.001	<.001	3	10
BONE	Endoderm development →	+0.189	+1.790	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,212 associations by consensus.

Peptidyl-threonine dephosphorylation by DUSP5 expression — OVARY

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