DUSP5

Across TCGA cell cohorts, DUSP5 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DUSP5-associated genes across cancer lineages are MAGEB4, CRISP1, and SEPTIN14. Each is linked with DUSP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUSP5-to-partner and partner-to-DUSP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by DUSP5-low versus DUSP5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUSP5→partner) and Y-score (partner→DUSP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.017	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CRISP1 →	+0.014	+4.415	<.001	.007	3	1
LARGE_INTESTINE	SEPTIN14 →	+0.011	+4.684	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

MAGEB4 by DUSP5 expression — LARGE_INTESTINE

Explore this box plot interactively →