DUSP3

Across TCGA pan-cancer cohorts, DUSP3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DUSP3 data layer compared with 27 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DUSP3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DUSP3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, LSCC, and PDAC are the cancer types where DUSP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	IV	0.785	0.123	.009	18	view →
LSCC	OS	Quartile	All	0.603	1.000	.013	4	view →
PDAC	DFS	Tertile	All	0.510	0.308	.042	4	view →
HNSC	DFS	Quartile	II,III,IV	0.883	0.980	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DUSP3–CCRCC (OS)

Open the CCRCC breakdown →