DUSP2

Across TCGA patient cohorts, DUSP2 mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DUSP2-associated genes across cancer lineages are MPP, CD4+ Tcm, and DC. Each is linked with DUSP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUSP2-to-partner and partner-to-DUSP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MPP grouped by DUSP2-low versus DUSP2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUSP2→partner) and Y-score (partner→DUSP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MPP →	+0.026	+4.694	<.001	.014	3	2
LUSC	CD4+ Tcm →	+0.009	+5.593	.004	.030	3	2
UCEC	DC →	+0.038	+3.103	.002	.020	3	2
SKCM	CD4+ Tem →	+0.102	+5.624	<.001	.039	3	1
UCEC	Neutrophils →	+0.016	+2.166	.006	.040	3	1
UCEC	CD8+ naive T-cells →	+0.051	+2.850	.002	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MPP by DUSP2 expression — LUSC

Explore this box plot interactively →