DUSP19

Across TCGA pan-cancer cohorts, DUSP19 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of DUSP19’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where DUSP19 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types DUSP19 is over-expressed in tumor, although a few such as PDAC and LSCC show the opposite, repressed pattern.

PDAC, LSCC, and CCRCC are the cancer types where DUSP19 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DUSP19 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	All	−0.824	<.001	8	view →
LSCC	Female	All	−0.389	<.001	7	view →
CCRCC	Male	All	+0.196	<.001	7	view →
LUAD	Female	All	−0.331	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

DUSP19–PDAC

Open the PDAC breakdown →