DUSP16

Across TCGA pan-cancer cohorts, DUSP16 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DUSP16 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher DUSP16 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DUSP16 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LSCC, LUAD, and HNSC are the cancer types where DUSP16 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	All	0.682	0.909	.003	11	view →
LUAD	OS	Median	II,III,IV	0.930	0.518	.032	6	view →
HNSC	DFS	Median	II,III,IV	0.830	0.506	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DUSP16–LSCC (OS)

Open the LSCC breakdown →