DUSP16

Across TCGA patient cohorts, DUSP16 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DUSP16-associated genes across cancer lineages are ACC1, ATM, and 4E-BP1. Each is linked with DUSP16 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUSP16-to-partner and partner-to-DUSP16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by DUSP16-low versus DUSP16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUSP16→partner) and Y-score (partner→DUSP16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.327	+2.713	.005	.003	3	2
UCEC	ATM →	-0.318	-1.222	.030	.035	3	2
UCEC	4E-BP1 →	+0.287	+3.029	.001	<.001	3	2
UCEC	eEF2 →	+0.276	+1.874	.017	.049	3	1
UCEC	EGFR_pY1068 →	-0.185	-2.115	.023	.016	3	1
UCEC	eIF4E →	+0.227	+2.700	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ACC1 by DUSP16 expression — UCEC

Explore this box plot interactively →