DUSP1

Across TCGA pan-cancer cohorts, DUSP1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DUSP1 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher DUSP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DUSP1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

PDAC, LUAD, and LSCC are the cancer types where DUSP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.269	0.887	.024	12	view →
LUAD	DFS	Quartile	All	0.307	1.000	.027	8	view →
LSCC	DFS	Median	II,III,IV	1.000	0.304	.006	5	view →
GBM	DFS	Quartile	All	0.286	0.600	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DUSP1–PDAC (DFS)

Open the PDAC breakdown →