DUSP1

Across TCGA patient cohorts, DUSP1 mutation is significantly associated with the RNA expression of many other genes, with 3,267 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DUSP1-associated genes across cancer lineages are SNORD115-2, RNU6-382P, and RNU6-648P. Each is linked with DUSP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUSP1-to-partner and partner-to-DUSP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD115-2 grouped by DUSP1-low versus DUSP1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUSP1→partner) and Y-score (partner→DUSP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SNORD115-2 →	+0.327	+8.055	<.001	.007	3	1
BRCA	RNU6-382P →	+0.358	+8.471	<.001	.005	3	1
BRCA	RNU6-648P →	+0.262	+8.055	<.001	.007	3	1
UCEC	YTHDF3-AS1 →	+0.731	+2.609	<.001	.006	3	1
UCEC	NBPF25P →	+0.244	+3.641	.006	.001	3	1
UCEC	POM121C →	+0.704	+3.849	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,267 associations by consensus.

SNORD115-2 by DUSP1 expression — BRCA

Explore this box plot interactively →