DUSP1

Across TCGA cell cohorts, DUSP1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DUSP1-associated genes across cancer lineages are C9orf92, SPHKAP, and KRT24. Each is linked with DUSP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUSP1-to-partner and partner-to-DUSP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf92 grouped by DUSP1-low versus DUSP1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUSP1→partner) and Y-score (partner→DUSP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	C9orf92 →	+0.194	+5.369	<.001	.004	3	1
BLOOD_Leukemia	SPHKAP →	+0.012	+4.922	<.001	.009	3	1
BLOOD_Leukemia	KRT24 →	+0.096	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR4F6 →	+0.018	+4.922	<.001	.009	3	1
BLOOD_Leukemia	SPPL2C →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	CSHL1 →	+0.035	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

C9orf92 by DUSP1 expression — SOFT_TISSUE

Explore this box plot interactively →