DUS3L

Across TCGA pan-cancer cohorts, DUS3L mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DUS3L data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DUS3L mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DUS3L expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

LUAD, PDAC, and CCRCC are the cancer types where DUS3L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.333	0.908	.002	10	view →
PDAC	DFS	Tertile	IV	0.934	0.236	.017	10	view →
CCRCC	OS	Tertile	All	0.959	0.793	.023	9	view →
HNSC	DFS	Median	II,III,IV	0.972	0.901	.039	5	view →
LSCC	OS	Median	All	0.899	0.760	.028	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DUS3L–LUAD (OS)

Open the LUAD breakdown →