DUS3L

Across TCGA patient cohorts, DUS3L mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DUS3L-associated genes across cancer lineages are ERK2, STAT3_pY705, and ATM. Each is linked with DUS3L in more than 1 cancer types. Because this analysis shows association rather than direction, both DUS3L-to-partner and partner-to-DUS3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by DUS3L-low versus DUS3L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUS3L→partner) and Y-score (partner→DUS3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.225	+2.700	.002	.006	3	2
UCEC	STAT3_pY705 →	-0.354	-1.584	<.001	.036	3	2
UCEC	ATM →	-0.395	-2.000	.026	.010	3	2
UCEC	EGFR_pY1068 →	-0.284	-2.000	.003	.010	3	1
UCEC	eIF4E →	+0.196	+3.183	.017	.009	3	1
UCEC	A-Raf_pS299 →	-0.201	-2.000	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ERK2 by DUS3L expression — UCEC

Explore this box plot interactively →