DUS3L

Across TCGA cell cohorts, DUS3L mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DUS3L-associated genes across cancer lineages are LRRC3C, CGB2, and CASQ2. Each is linked with DUS3L in more than 1 cancer types. Because this analysis shows association rather than direction, both DUS3L-to-partner and partner-to-DUS3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC3C grouped by DUS3L-low versus DUS3L-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUS3L→partner) and Y-score (partner→DUS3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LRRC3C →	+0.305	+4.099	<.001	.001	3	2
BLOOD_Leukemia	CGB2 →	+0.751	+3.234	<.001	.008	3	1
BLOOD_Leukemia	CASQ2 →	+0.071	+3.926	<.001	.003	3	1
BLOOD_Leukemia	OR11H1 →	+0.052	+4.201	<.001	.001	3	1
BLOOD_Leukemia	TRPC6 →	+0.748	+4.169	<.001	.003	3	1
BLOOD_Leukemia	C1QL2 →	+0.011	+3.922	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

LRRC3C by DUS3L expression — LARGE_INTESTINE

Explore this box plot interactively →