DUS1L

Across TCGA pan-cancer cohorts, DUS1L mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DUS1L data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DUS1L mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DUS1L expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where DUS1L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.666	0.867	.002	29	view →
LSCC	OS	Median	II,III,IV	0.888	0.595	.006	15	view →
PDAC	OS	Median	III,IV	0.618	0.889	.005	13	view →
LUAD	DFS	Quartile	III,IV	0.645	0.964	.019	8	view →
CCRCC	OS	Tertile	II,III,IV	0.710	0.902	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DUS1L–HNSC (DFS)

Open the HNSC breakdown →