DUOX2

mass-spec protein — tumor vs normal
Tumor vs Normalmass-specBox plot · TCGA cohorts

Across TCGA pan-cancer cohorts, DUOX2 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of DUOX2’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where DUOX2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types DUOX2 is over-expressed in tumor.

PDAC and LSCC are the cancer types where DUOX2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DUOX2 mass-spec protein (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.
LineageGenderStageFold-changepSampling consensus
PDACAllII,III,IV+0.767<.0017view →
LSCCAllAll+0.617.0063view →
Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

DUOX2–PDAC

Tumor-vs-normal mass-spec protein box plot for DUOX2 in PDAC.

Open the PDAC breakdown →

Exploration