DUOX2

Across TCGA patient cohorts, DUOX2 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,889 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible DUOX2-associated proteins across cancer lineages are DUOXA2_S296, SPRR3, and UBE2O. Each is linked with DUOX2 in more than 3 cancer types. Because this analysis shows association rather than direction, both DUOX2-to-partner and partner-to-DUOX2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DUOX2 versus DUOXA2_S296 in LSCC, with a Pearson correlation of 0.81.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DUOX2→partner) and Y-score (partner→DUOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DUOXA2_S296 →	+2.277	+1.605	<.001	<.001	3	4
UCEC	SPRR3 →	+2.020	+0.759	<.001	.002	3	3
LUAD	UBE2O →	-0.208	-0.950	<.001	.004	3	3
LUAD	UNG →	-0.361	-0.924	.001	.002	3	3
CCRCC	MYO1D →	+0.425	+0.119	<.001	.004	3	3
LSCC	IFI16_S106 →	+0.591	+1.035	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,889 associations by consensus.

DUOX2 vs DUOXA2_S296 — LSCC

Explore this scatter interactively →