DUOX2

Across TCGA patient cohorts, DUOX2 protein abundance is significantly associated with the RNA expression of many other genes, with 8,542 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DUOX2-associated genes across cancer lineages are DUOXA2, DHRS9, and VNN3. Each is linked with DUOX2 in more than 3 cancer types. Because this analysis shows association rather than direction, both DUOX2-to-partner and partner-to-DUOX2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DUOX2 versus DUOXA2 in LUAD, with a Pearson correlation of 0.85.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUOX2→partner) and Y-score (partner→DUOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DUOXA2 →	+4.207	+3.942	<.001	<.001	3	4
LSCC	DHRS9 →	+2.099	+2.020	<.001	<.001	3	4
LUAD	VNN3 →	+2.222	+2.555	.008	.005	3	4
HNSC	CEACAM7 →	+2.265	+0.914	<.001	.001	3	4
LUAD	VNN1 →	+4.045	+3.920	<.001	<.001	3	3
LUAD	EPS8L1 →	+1.986	+3.727	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,542 associations by consensus.

DUOX2 vs DUOXA2 — LUAD

Explore this scatter interactively →