DUOX2

Across TCGA patient cohorts, DUOX2 mutation is significantly associated with the total protein of many other genes, with 81 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DUOX2-associated genes across cancer lineages are A-Raf_pS299, GAPDH, and INPP4B. Each is linked with DUOX2 in more than 3 cancer types. Because this analysis shows association rather than direction, both DUOX2-to-partner and partner-to-DUOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by DUOX2-low versus DUOX2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUOX2→partner) and Y-score (partner→DUOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	A-Raf_pS299 →	-0.268	-2.990	.038	.036	3	3
COAD	GAPDH →	+0.761	+2.597	<.001	.005	2	4
COAD	INPP4B →	-0.431	-2.213	.002	.010	3	3
COAD	PCNA →	+0.254	+2.915	.007	<.001	3	3
COAD	ATM →	-0.531	-1.874	<.001	.047	3	3
COAD	Caspase-7-cleavedD198 →	+1.304	+3.476	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

A-Raf_pS299 by DUOX2 expression — LUSC

Explore this box plot interactively →