DUOX2

Across TCGA cell cohorts, DUOX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,433 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DUOX2-associated GO terms across cancer lineages are Cellular response to steroid hormone stimulus, Positive regulation of hydrogen peroxide biosynthetic process, and Negative regulation of myoblast fusion. Each is linked with DUOX2 in more than 11 cancer types. Because this analysis shows association rather than direction, both DUOX2-to-partner and partner-to-DUOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to steroid hormone stimulus grouped by DUOX2-low versus DUOX2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DUOX2→partner) and Y-score (partner→DUOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Cellular response to steroid hormone stimulus →	+0.073	+0.574	<.001	.009	3	12
BONE	Positive regulation of hydrogen peroxide biosynthetic process →	-0.168	-0.674	<.001	<.001	3	11
BREAST	Negative regulation of myoblast fusion →	+0.121	+0.454	<.001	.007	3	10
LUNG_SCLC	Regulation of syncytium formation by plasma membrane fusion →	+0.099	+0.280	<.001	.005	2	11
PANCREAS	Viral process →	+0.090	+0.827	<.001	<.001	3	9
PANCREAS	Negative regulation of response to endoplasmic reticulum stress →	+0.099	+0.565	.005	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,433 associations by consensus.

Cellular response to steroid hormone stimulus by DUOX2 expression — PANCREAS

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