DUOX1

Across TCGA pan-cancer cohorts, DUOX1 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated DUOX1 data layer compared with 24 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher DUOX1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DUOX1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LAML show a favorable association.

KIRP, DLBC, and UCEC are the cancer types where DUOX1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	II,III,IV	0.148	0.771	<.001	30	view →
DLBC	OS	Median	II,III,IV	0.172	0.949	<.001	30	view →
UCEC	DFS	Median	All	0.951	0.824	.010	18	view →
SCLC	OS	Median	All	0.301	0.711	.018	12	view →
BLCA	OS	Median	IV	0.052	0.590	<.001	12	view →
ESCA	DFS	Median	II,III,IV	0.089	0.522	.001	12	view →
LAML	DFS	Median	All	1.000	0.357	.045	4	view →
HNSC	OS	Median	II,III,IV	0.254	0.604	.037	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

DUOX1–KIRP (OS)

Open the KIRP breakdown →