DUOX1

Across TCGA pan-cancer cohorts, DUOX1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DUOX1 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DUOX1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DUOX1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where DUOX1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.919	0.773	.006	31	view →
LUAD	DFS	Quartile	All	0.894	0.965	.014	8	view →
LSCC	DFS	Median	II,III,IV	0.485	1.000	.006	5	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DUOX1–HNSC (OS)

Open the HNSC breakdown →