DUOX1

Across TCGA patient cohorts, DUOX1 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,075 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DUOX1-associated proteins across cancer lineages are SERPINB5, NEBL, and DUOX1_S634. Each is linked with DUOX1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DUOX1-to-partner and partner-to-DUOX1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DUOX1 versus SERPINB5 in LSCC, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DUOX1→partner) and Y-score (partner→DUOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SERPINB5 →	+1.049	+0.775	<.001	.001	3	4
UCEC	NEBL →	+0.755	+0.849	.001	.004	3	4
LSCC	DUOX1_S634 →	+1.449	+0.928	<.001	<.001	3	4
HNSC	IQGAP1 →	+0.261	+1.030	<.001	<.001	3	4
HNSC	WDFY2 →	+0.177	+0.586	.005	<.001	3	3
LUAD	YOD1 →	+0.343	+0.965	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,075 associations by consensus.

DUOX1 vs SERPINB5 — LSCC

Explore this scatter interactively →