DUOX1

Across TCGA patient cohorts, DUOX1 protein abundance is significantly associated with the RNA expression of many other genes, with 9,405 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible DUOX1-associated genes across cancer lineages are DUOXA1, DUOXA2, and XRCC2. Each is linked with DUOX1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DUOX1-to-partner and partner-to-DUOX1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DUOX1 versus DUOXA1 in LUAD, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUOX1→partner) and Y-score (partner→DUOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DUOXA1 →	+1.432	+0.428	<.001	<.001	3	4
UCEC	DUOXA2 →	+1.198	+1.686	.001	<.001	3	4
UCEC	XRCC2 →	-1.181	-1.325	<.001	<.001	3	4
OV	ZNF182 →	-0.742	-2.118	<.001	.001	3	3
LSCC	HPD →	-0.613	-0.393	.004	<.001	3	3
OV	RELA-DT →	-0.717	-1.924	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,405 associations by consensus.

DUOX1 vs DUOXA1 — LUAD

Explore this scatter interactively →