DUOX1

Across TCGA patient cohorts, DUOX1 mutation is significantly associated with the total protein of many other genes, with 76 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DUOX1-associated genes across cancer lineages are Notch1, PCNA, and PDCD4. Each is linked with DUOX1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DUOX1-to-partner and partner-to-DUOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by DUOX1-low versus DUOX1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUOX1→partner) and Y-score (partner→DUOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Notch1 →	+0.186	+3.000	.006	.033	3	4
COAD	PCNA →	+0.208	+2.815	.032	.001	3	4
UCEC	PDCD4 →	-0.456	-1.722	<.001	<.001	3	3
COAD	eEF2 →	+0.328	+2.204	.004	.031	3	3
COAD	Lck →	+0.260	+3.000	.030	.035	3	3
COAD	ASNS →	+0.430	+1.593	.005	.043	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

Notch1 by DUOX1 expression — STAD

Explore this box plot interactively →