DUOX1

Across TCGA cell cohorts, DUOX1 mutation is significantly associated with the RNA expression of many other genes, with 356 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DUOX1-associated genes across cancer lineages are OR1L1, GSX1, and NANOS2. Each is linked with DUOX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUOX1-to-partner and partner-to-DUOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L1 grouped by DUOX1-low versus DUOX1-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUOX1→partner) and Y-score (partner→DUOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	OR1L1 →	+0.033	+5.169	<.001	.004	3	2
BLOOD_Leukemia	GSX1 →	+1.074	+4.622	<.001	<.001	3	2
BLOOD_Leukemia	NANOS2 →	+0.037	+3.455	<.001	.002	3	2
BLOOD_Leukemia	H2AB1 →	+0.501	+3.594	<.001	.007	3	2
LARGE_INTESTINE	SH3GL2 →	+1.158	+3.667	<.001	<.001	3	2
LARGE_INTESTINE	SPEM3 →	+0.009	+2.610	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 356 associations by consensus.

OR1L1 by DUOX1 expression — BONE

Explore this box plot interactively →