DTYMK

Across TCGA pan-cancer cohorts, DTYMK mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DTYMK data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DTYMK mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DTYMK expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

LUAD, PDAC, and UCEC are the cancer types where DTYMK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	All	0.679	0.967	.004	20	view →
PDAC	DFS	Quartile	II,III,IV	0.596	0.903	.017	14	view →
UCEC	OS	Quartile	III,IV	1.000	0.250	.020	12	view →
CCRCC	OS	Median	II,III,IV	0.327	0.917	.015	5	view →
HNSC	OS	Median	III,IV	0.449	1.000	.023	4	view →
GBM	DFS	Median	All	0.282	0.454	.022	3	view →
LSCC	DFS	Median	II,III,IV	0.807	0.575	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DTYMK–LUAD (OS)

Open the LUAD breakdown →