DTYMK

Across TCGA patient cohorts, DTYMK mutation is significantly associated with the RNA expression of many other genes, with 520 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DTYMK-associated genes across cancer lineages are NOCT, SLC25A4, and FARP1. Each is linked with DTYMK in more than 1 cancer types. Because this analysis shows association rather than direction, both DTYMK-to-partner and partner-to-DTYMK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOCT grouped by DTYMK-low versus DTYMK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTYMK→partner) and Y-score (partner→DTYMK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NOCT →	+0.952	+3.332	<.001	.005	3	1
UCEC	SLC25A4 →	+0.756	+3.332	.001	.005	3	1
UCEC	FARP1 →	+0.700	+3.332	.002	.005	3	1
UCEC	NTAN1 →	+0.668	+3.375	<.001	.005	3	1
UCEC	EYA3 →	+0.571	+3.343	.005	.005	3	1
UCEC	ZNF221 →	+0.419	+3.343	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 520 associations by consensus.

NOCT by DTYMK expression — UCEC

Explore this box plot interactively →