DTYMK

Across TCGA patient cohorts, DTYMK mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DTYMK-associated genes across cancer lineages are PRAS40_pT246, STAT3_pY705, and C-Raf_pS338. Each is linked with DTYMK in more than 1 cancer types. Because this analysis shows association rather than direction, both DTYMK-to-partner and partner-to-DTYMK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAS40_pT246 grouped by DTYMK-low versus DTYMK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTYMK→partner) and Y-score (partner→DTYMK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAS40_pT246 →	+0.200	+3.013	.044	.019	3	1
UCEC	STAT3_pY705 →	-0.344	-3.000	.023	.037	3	1
UCEC	C-Raf_pS338 →	-0.127	-3.000	.007	.037	3	1
UCEC	Chk2_pT68 →	-0.220	-3.000	.041	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

PRAS40_pT246 by DTYMK expression — UCEC

Explore this box plot interactively →