DTX3L

Across TCGA pan-cancer cohorts, DTX3L mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DTX3L data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DTX3L mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DTX3L expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

CCRCC, PDAC, and GBM are the cancer types where DTX3L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	IV	0.451	1.000	.016	13	view →
PDAC	OS	Median	IV	0.491	0.836	.024	6	view →
GBM	DFS	Tertile	All	0.657	0.753	.015	5	view →
LSCC	DFS	Tertile	All	0.988	0.492	.016	4	view →
LUAD	OS	Median	All	0.972	0.916	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DTX3L–CCRCC (OS)

Open the CCRCC breakdown →