DTX3L

Across TCGA patient cohorts, DTX3L mutation is significantly associated with the RNA expression of many other genes, with 2,121 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DTX3L-associated genes across cancer lineages are RN7SKP221, GPATCH11, and BUB3. Each is linked with DTX3L in more than 2 cancer types. Because this analysis shows association rather than direction, both DTX3L-to-partner and partner-to-DTX3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP221 grouped by DTX3L-low versus DTX3L-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTX3L→partner) and Y-score (partner→DTX3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SKP221 →	+0.099	+8.471	<.001	.005	3	2
UCEC	GPATCH11 →	+0.485	+3.130	<.001	<.001	3	2
UCEC	BUB3 →	+0.569	+3.075	<.001	<.001	3	2
UCEC	ZC3H18 →	+0.501	+2.354	<.001	<.001	3	2
UCEC	RNF166 →	+0.504	+2.343	<.001	<.001	3	2
UCEC	NAE1 →	+0.533	+2.855	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,121 associations by consensus.

RN7SKP221 by DTX3L expression — BRCA

Explore this box plot interactively →