DTX3L

Across TCGA patient cohorts, DTX3L mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DTX3L-associated genes across cancer lineages are ERK2, Rab11, and EGFR_pY1068. Each is linked with DTX3L in more than 1 cancer types. Because this analysis shows association rather than direction, both DTX3L-to-partner and partner-to-DTX3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by DTX3L-low versus DTX3L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTX3L→partner) and Y-score (partner→DTX3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.193	+2.000	.008	.029	3	2
UCEC	Rab11 →	-0.114	-1.678	.041	.023	3	2
UCEC	EGFR_pY1068 →	-0.252	-2.700	.008	.006	3	1
UCEC	eIF4E →	+0.219	+3.807	.006	<.001	3	1
UCEC	FASN →	+0.360	+2.999	.017	.035	3	1
UCEC	FoxM1 →	+0.229	+2.584	.021	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

ERK2 by DTX3L expression — UCEC

Explore this box plot interactively →