DTX3L

Across TCGA cell cohorts, DTX3L RNA expression is significantly associated with the go_rna of many other GO terms, with 5,522 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DTX3L-associated GO terms across cancer lineages are Positive regulation of interleukin-4-mediated signaling pathway, Regulation of cytokine-mediated signaling pathway, and Cytoplasmic pattern recognition receptor signaling pathway. Each is linked with DTX3L in more than 17 cancer types. Because this analysis shows association rather than direction, both DTX3L-to-partner and partner-to-DTX3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of interleukin-4-mediated signaling pathway grouped by DTX3L-low versus DTX3L-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DTX3L→partner) and Y-score (partner→DTX3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of interleukin-4-mediated signaling pathway →	+1.545	+1.857	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Regulation of cytokine-mediated signaling pathway →	+0.075	+1.152	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Cytoplasmic pattern recognition receptor signaling pathway →	+0.080	+0.988	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Negative regulation of viral genome replication →	+0.201	+1.154	<.001	<.001	3	18
STOMACH	Positive regulation of cytokine-mediated signaling pathway →	+0.120	+1.678	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Regulation of response to cytokine stimulus →	+0.073	+1.107	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,522 associations by consensus.

Positive regulation of interleukin-4-mediated signaling pathway by DTX3L expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →