DTX3

Across TCGA patient cohorts, DTX3 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DTX3-associated genes across cancer lineages are Cyclin-B1, EGFR_pY1068, and FoxM1. Each is linked with DTX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DTX3-to-partner and partner-to-DTX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by DTX3-low versus DTX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTX3→partner) and Y-score (partner→DTX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.825	+3.321	<.001	.009	3	2
UCEC	EGFR_pY1068 →	-0.272	-3.321	.013	.009	3	1
UCEC	FoxM1 →	+0.266	+2.115	.018	.019	3	1
UCEC	Ku80 →	+0.295	+2.128	.004	.010	3	1
UCEC	mTOR_pS2448 →	-0.152	-2.807	.019	.003	3	1
UCEC	PCNA →	+0.287	+2.115	.002	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Cyclin-B1 by DTX3 expression — UCEC

Explore this box plot interactively →