DTX1

Across TCGA patient cohorts, DTX1 mutation is significantly associated with the RNA expression of many other genes, with 2,227 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DTX1-associated genes across cancer lineages are MIR8070, CENPU, and ZNF367. Each is linked with DTX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DTX1-to-partner and partner-to-DTX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8070 grouped by DTX1-low versus DTX1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTX1→partner) and Y-score (partner→DTX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR8070 →	+0.698	+4.594	<.001	.004	3	3
UCEC	CENPU →	+0.612	+2.949	.001	<.001	3	3
UCEC	ZNF367 →	+0.736	+2.928	<.001	<.001	3	3
HNSC	RPL21P66 →	+0.107	+5.266	<.001	.001	3	3
UCEC	STIP1P3 →	+0.357	+1.821	<.001	.007	3	3
DLBC	NMBR-AS1 →	+0.246	+3.906	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,227 associations by consensus.

MIR8070 by DTX1 expression — HNSC

Explore this box plot interactively →