DTX1

Across TCGA patient cohorts, DTX1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DTX1-associated genes across cancer lineages are PDCD4, C-Raf, and eEF2. Each is linked with DTX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DTX1-to-partner and partner-to-DTX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by DTX1-low versus DTX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTX1→partner) and Y-score (partner→DTX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.469	-2.000	.004	.029	3	3
UCEC	C-Raf →	+0.171	+2.000	<.001	.003	3	3
UCEC	eEF2 →	+0.359	+1.662	.004	.011	3	2
UCEC	GAPDH →	+0.474	+1.700	.012	.040	3	2
UCEC	RBM15 →	+0.238	+2.115	.034	.017	3	2
UCEC	Smad3 →	+0.128	+2.584	.016	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

PDCD4 by DTX1 expression — UCEC

Explore this box plot interactively →