DTX1

Across TCGA cell cohorts, DTX1 mutation is significantly associated with the RNA expression of many other genes, with 1,187 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DTX1-associated genes across cancer lineages are IFNL2, MMP27, and RETNLB. Each is linked with DTX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DTX1-to-partner and partner-to-DTX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNL2 grouped by DTX1-low versus DTX1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTX1→partner) and Y-score (partner→DTX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	IFNL2 →	+0.654	+5.169	<.001	.001	3	2
PANCREAS	MMP27 →	+0.005	+4.614	<.001	.004	3	1
PANCREAS	RETNLB →	+0.106	+4.237	.001	.006	3	1
PANCREAS	TBL1Y →	+0.005	+4.614	<.001	.004	3	1
LUNG_NSCLC_LUSC	UTF1 →	+0.136	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,187 associations by consensus.

IFNL2 by DTX1 expression — BLOOD_Lymphoma

Explore this box plot interactively →