DTWD1

Across TCGA pan-cancer cohorts, DTWD1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DTWD1 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher DTWD1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DTWD1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where DTWD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.487	0.245	.001	62	view →
CCRCC	DFS	Tertile	All	1.000	0.672	.013	10	view →
HNSC	OS	Quartile	IV	0.595	0.878	.021	4	view →
LUAD	DFS	Tertile	III,IV	0.690	0.297	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DTWD1–PDAC (DFS)

Open the PDAC breakdown →