DTNBP1

Across TCGA pan-cancer cohorts, DTNBP1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DTNBP1 data layer compared with 28 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher DTNBP1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated DTNBP1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

STAD, UCEC, and SKCM are the cancer types where DTNBP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Median	All	0.212	0.658	.003	12	view →
UCEC	DFS	Median	All	1.000	0.633	.021	8	view →
SKCM	DFS	Median	III,IV	0.062	0.602	<.001	8	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
ESCA	DFS	Median	II,III,IV	0.190	0.525	.032	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DTNBP1–STAD (DFS)

Open the STAD breakdown →