DTNBP1

Across TCGA pan-cancer cohorts, DTNBP1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DTNBP1 data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher DTNBP1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DTNBP1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

GBM, LUAD, and UCEC are the cancer types where DTNBP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Quartile	All	0.323	0.671	.002	22	view →
LUAD	OS	Tertile	III,IV	1.000	0.391	.009	15	view →
UCEC	DFS	Quartile	All	1.000	0.766	.004	10	view →
HNSC	DFS	Median	II,III,IV	0.555	0.761	.012	9	view →
LSCC	DFS	Quartile	II,III,IV	0.888	0.200	.024	7	view →
PDAC	DFS	Quartile	All	0.879	0.691	.019	6	view →
CCRCC	DFS	Median	II,III,IV	0.955	0.789	.023	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DTNBP1–GBM (OS)

Open the GBM breakdown →