DTNBP1

Across TCGA cell cohorts, DTNBP1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DTNBP1-associated genes across cancer lineages are CPLX4, MBD3L2, and MAGEB10. Each is linked with DTNBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DTNBP1-to-partner and partner-to-DTNBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CPLX4 grouped by DTNBP1-low versus DTNBP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTNBP1→partner) and Y-score (partner→DTNBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CPLX4 →	+0.026	+2.444	<.001	.008	3	1
LARGE_INTESTINE	MBD3L2 →	+0.043	+3.415	<.001	.001	3	1
LUNG_NSCLC_LUAD	MAGEB10 →	+0.021	+4.544	.002	.003	3	1
LUNG_NSCLC_LUAD	LCE1B →	+0.034	+4.371	.001	.005	3	1
LUNG_NSCLC_LUAD	PRAMEF19 →	+0.012	+4.662	<.001	.005	3	1
LARGE_INTESTINE	FAM170A →	+0.080	+2.807	<.001	.004	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

CPLX4 by DTNBP1 expression — LARGE_INTESTINE

Explore this box plot interactively →