DTNA

Across TCGA pan-cancer cohorts, DTNA Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated DTNA data layer compared with 22 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DTNA Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DTNA expression acts as an unfavorable survival marker, although some lineages such as UCEC and UCS show a favorable association.

HNSC, ESCA, and UCEC are the cancer types where DTNA Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.170	0.745	<.001	63	view →
ESCA	OS	Median	II,III,IV	0.074	0.687	<.001	39	view →
UCEC	DFS	Median	All	0.921	0.608	.001	34	view →
LUAD	DFS	Median	IV	0.045	0.717	<.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LIHC	DFS	Median	II,III,IV	0.044	0.414	<.001	6	view →
UCS	DFS	Median	All	0.799	0.225	.040	4	view →
SKCM	OS	Median	All	0.679	0.791	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

DTNA–HNSC (OS)

Open the HNSC breakdown →