Across TCGA pan-cancer cohorts, DTHD1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DTHD1 data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher DTHD1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DTHD1 expression acts as an unfavorable survival marker.

LSCC, LUAD, and PDAC are the cancer types where DTHD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.781	1.000	.006	11	view →
LUAD	DFS	Median	II,III,IV	0.804	1.000	.038	7	view →
PDAC	OS	Median	All	0.462	0.880	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: DTHD1 tumor-vs-normal RNA expression · all DTHD1 data types