Across TCGA patient cohorts, DTHD1 mutation is significantly associated with the RNA expression of many other genes, with 1,520 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DTHD1-associated genes across cancer lineages are SLC25A4, SKA1, and ABHD3. Each is linked with DTHD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DTHD1-to-partner and partner-to-DTHD1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTHD1→partner) and Y-score (partner→DTHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC25A4 →	+0.463	+2.024	.001	.001	3	2
COAD	SKA1 →	+0.724	+3.335	.001	.005	3	2
UCEC	ABHD3 →	+0.494	+1.949	.004	.001	3	2
UCEC	MIS18A →	+0.433	+1.652	.008	.006	3	2
UCEC	DONSON →	+0.459	+2.032	.001	.004	3	2
UCEC	CHAF1B →	+0.496	+1.864	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,520 associations by consensus.

Exploration

DTHD1 survival (RNA) · tumor vs normal (RNA) · all DTHD1 data types