DTD2

Across TCGA patient cohorts, DTD2 mutation is significantly associated with the RNA expression of many other genes, with 97 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DTD2-associated genes across cancer lineages are C22orf46, SMYD4, and ZKSCAN5. Each is linked with DTD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DTD2-to-partner and partner-to-DTD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C22orf46 grouped by DTD2-low versus DTD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTD2→partner) and Y-score (partner→DTD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C22orf46 →	+0.544	+3.343	.003	.005	3	1
UCEC	SMYD4 →	+0.475	+3.364	.005	.005	3	1
UCEC	ZKSCAN5 →	+0.487	+3.354	.001	.005	3	1
UCEC	TEX43 →	+0.297	+2.343	<.001	.008	3	1
UCEC	RNA5SP493 →	+0.554	+2.842	<.001	.002	3	1
UCEC	RNU6-1082P →	+0.295	+3.136	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 97 associations by consensus.

C22orf46 by DTD2 expression — UCEC

Explore this box plot interactively →