DTD2

Across TCGA patient cohorts, DTD2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DTD2-associated genes across cancer lineages are JNK2, c-Met_pY1235, and p38-MAPK_pT180_Y182. Each is linked with DTD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DTD2-to-partner and partner-to-DTD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by DTD2-low versus DTD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTD2→partner) and Y-score (partner→DTD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.292	+3.000	.011	.037	3	1
UCEC	c-Met_pY1235 →	+0.101	+3.009	.019	.019	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.576	-2.986	.026	.037	2	1
UCEC	VHL →	-1.197	-3.000	.002	.037	2	1
UCEC	HER3_pY1289 →	+0.146	+3.026	.003	.019	1	1
UCEC	MAPK_pT202_Y204 →	-0.558	-3.000	.039	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

JNK2 by DTD2 expression — UCEC

Explore this box plot interactively →