DTD2

Across TCGA cell cohorts, DTD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,950 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DTD2-associated GO terms across cancer lineages are Regulation of translational fidelity, Aminoacyl-tRNA metabolism involved in translational fidelity, and Interstrand cross-link repair. Each is linked with DTD2 in more than 13 cancer types. Because this analysis shows association rather than direction, both DTD2-to-partner and partner-to-DTD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of translational fidelity grouped by DTD2-low versus DTD2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DTD2→partner) and Y-score (partner→DTD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of translational fidelity →	+0.117	+1.361	<.001	<.001	3	14
LIVER	Aminoacyl-tRNA metabolism involved in translational fidelity →	+0.135	+1.404	.002	.004	2	14
LUNG_NSCLC_LUSC	Interstrand cross-link repair →	+0.093	+1.407	.007	.001	3	10
BREAST	External encapsulating structure organization →	-0.114	-0.853	.001	<.001	3	10
BLOOD_Lymphoma	Ubiquitin-dependent protein catabolic process via the N-end rule pathway →	+0.059	+0.844	.004	.002	3	10
OESOPHAGUS	rRNA 5'-end processing →	+0.113	+1.077	.009	.004	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,950 associations by consensus.

Regulation of translational fidelity by DTD2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →