DTD1

Across TCGA pan-cancer cohorts, DTD1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DTD1 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DTD1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DTD1 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

HNSC, GBM, and LUAD are the cancer types where DTD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.374	0.979	.003	49	view →
GBM	OS	Tertile	All	0.665	0.375	.005	12	view →
LUAD	OS	Tertile	III,IV	0.359	0.879	.008	8	view →
CCRCC	OS	Quartile	III,IV	0.564	0.970	.010	6	view →
LSCC	DFS	Tertile	III,IV	0.839	1.000	.034	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DTD1–HNSC (OS)

Open the HNSC breakdown →