DTD1

Across TCGA patient cohorts, DTD1 mutation is significantly associated with the RNA expression of many other genes, with 1,186 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DTD1-associated genes across cancer lineages are IL9, RNU6-218P, and RNU6-777P. Each is linked with DTD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DTD1-to-partner and partner-to-DTD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL9 grouped by DTD1-low versus DTD1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTD1→partner) and Y-score (partner→DTD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IL9 →	+0.155	+4.354	.005	.007	3	2
UCEC	RNU6-218P →	+0.508	+2.278	<.001	.001	3	2
LUSC	RNU6-777P →	+0.755	+7.102	<.001	<.001	3	2
LUSC	MIR1305 →	+0.626	+5.474	<.001	.005	3	2
LUSC	RN7SL214P →	+0.256	+5.706	<.001	.003	3	2
HNSC	CYCSP22 →	+0.113	+6.111	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,186 associations by consensus.

IL9 by DTD1 expression — COAD

Explore this box plot interactively →